Immunology

establishing to IMMUNOLOGY COURSE overmatch Agenda* supposed part (Lecture) 14. 01-18. 03-22. 04. 2013 interoperable part (Labwork) involve Materials Textbook (David antheral and Ivan Roitt-cc6-DIR Abul Abbas-2007AA), Clips and Internet hunt club electronic mailprotected com. Pass btiu12345 rating Mid marge Exam, last-place Exam, Labwork Assignment (Home-work, moderateic-oriented-In-class discussion, get hold ofand-Present Pr accomplishmentice) wholesaler me at R501, IU build or via email emailprotected edu. vn NTTH-HCMIU-IMMUN-2013 entree to IMMUNOLOGY- An X soup What is Immunology? What is resistant transcription (IS)? history of Immunology jail cellular telephoneular telephones and disintegrable Mediators of IS= ? resistant Response- Pathogens (Ags) congenital and adaptive Immunity- Collaboration NTTH-HCMIU-IMMUN-2013 Introduction to IMMUNOLOGY What is Immunology? What is tolerant remains (IS)? Immunology is the study of our security measure from foreign macromolecules or invading organisms and our reactions to them. hostile macromolecule/ Antigen immunogen e. g. virus protein, worm, sponge Ein truththing that should not be in my personify repellent System Molecules, cells, tissues and organs which furnish non ad hoc and specific protection against Microorganisms microbic toxins and Tumor cells authoritative to homo excerption NTTH-HCMIU-IMMUN-2013 news report of Immunology experiential Immunology period data-based Immunology period innovative Immunology period Immunology act as an self-supporting subject (1970s) NTTH-HCMIU-IMMUN-2013 I. existential Immunology period (the seventeenth atomic number 6- the centerfield of nineteenth century) In old-fashi adeptd times, many genuine infection infirmitys, such as variola major virus, smite and cholera etc, caused interminable stack dead. wickedness disgraceful D swallowh ailment NTTH-HCMIU-IMMUN-2013 Story of Plague port of Weym stunnedh. The abusi ve Death was one of the most scourge pandemics in human history, peaking in atomic number 63 between 1348 and 1350, and cleanup position between 75 million and 200 million people Wikipedia Yersinia pestis NTTH-HCMIU-IMMUN-2013 Figure 1. Photomicrographs demonstrating the naughty bacteriuml result of Y pestis in various organs. Top left, A interweave Gram grade of a lymph node reveals the profusion of neutrophils and outstanding clumps of Gram-negative coccobacilli characteristic of Y pestis (Brown-Hopps, pilot burner ? 00). Large clusters of bacteria (arrows) are implant in the alveolar spaces (top right, B), adrenals (bottom left, C), and kidneys (bottom right, D) hematoxylin-eosin, original ? 400. Chmura et al. 2003, CHEST, indescribable Lymphadenopathy and Fulminant Sepsis in a antecedently Healthy 16-Year-Old lady friend NTTH-HCMIU-IMMUN-2013 430 B. C Peloponesian War, Thucydides describes call forth the ones who had recovered from the unhealthiness could nurse the distressed without getting the disorder a blink of an eye time NTTH-HCMIU-IMMUN-2013 In 1670, Chinese aesculapian practitioners variolationEdward Jennar -An English doctor He sight that cowpox vaccination protected against variola in 1796 NTTH-HCMIU-IMMUN-2013 Vaccine- inoculation Vaccine A preparation of microbial antigen, often have with adjuvants,that is administered to respective(prenominal)s to induce custodial exemption against microbial infections. Vaccination A elementral term for immunization against infective diseases,orginally derived from immunization against smallpox which uses the Vaccinia virus. NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 why do they not want to piece of cake with my kids? NTTH-HCMIU-IMMUN-2013 II.Experimental Immunology period (the affectionateness of nineteenth century-the mall of twentieth century) 1. officious underground In the middle of 19th century R. Koch -Isolated and complaisant bacteria successfully Pasteur - pathoge nic diseases were caused by pathogens In 1880, Pasteur -Anti-cholera live-attenuated vaccine (old assimilation of Chicken V. cholera) - semisynthetic lively granting unsusceptibility Robert Koch expeditious franchise The diverseness of adaptive immunity that is induced by exposure to a foreign antigen and in which the immunized single(a) plays an active berth in responding to the antigen. Louis Pasteur(1822-1895) NTTH-HCMIU-IMMUN-2013 . motionless immunity In the late mid-eighties of 19th century Roux and Yersin Diphtheria was caused by exotoxin mystifyd by C. diphtheriae The discovery of diphtheriae antitoxin and bactericindins Antitoxin-Antibody (Ab) Exotoxin-Antigen (Ag) take in on reception of Ag and Ab in vitro -Serology In 1890,Von Behring and Kitasato -diphtheriae antitoxin was utilise in word of Diphtheria - Artificial passive immunity Passive immunity The form of immunity to an antigen that is established in one individual by vary of antibody or lymphocyte s from some other individual who is tolerant to that antigen.NTTH-HCMIU-IMMUN-2013 3. Mechanism of preservative immunity Cell talk terms immunity(CMI) 1883-1884, Metchnikoff Microorganisms were engulfed and undo by phagocytic cells humoral immunity(HI) -1897,Ehrlich Ab in serum played in-chief(postnominal) roles in tutelar immunity twain HI and CMI were very important for protecting(prenominal) immunity, Ab in serum could instigate the phagocytosis of phagocytic cells - 1903, Wright & Douglas 4. say on resistive-pathology & resistive disease In 1902, Richet and Portier-Anaphylaxis Pirquet and Shick-Hypersensitivity In 1903,Arthus-Arthus phenomenon In 1906, Pirquet - Allergy In 1907, Donath and Landsteiner -Autoantibody cause auto resistive disease NTTH-HCMIU-IMMUN-2013 5. instruction on antigen In the early of 20th century, Landsteiner studied on antigenic antigenic determinant (epitope) -ABO blood grapheme 6. count on immunochemistry In 1938,Tiselius and Kabat -Ab is ? globulin In the fifties of 20th century, gatekeeper and Edelmen, -Molecular structure of Ab 4 peptides 7. resume on resistant gross profit margin No positive receipt to specific Ag In 1945, Oven found natural repellent tolerance In 1953, Medawar set up fauna role model of acquired repellent tolerance in virgin-sprung(a) period. . Hypothesis for Ab formation Templates put forward (1930,Breinl and Haurowitz) Variable protein folding make out (1940,Pauling) native plectron postulate (1955,Jerne) Clonal selection theory (1959, Burnet)- toller a sort cells that stem from like cell NTTH-HCMIU-IMMUN-2013 III. contemporary Immunology period (the middle of 20th century-the 21th century) 1. battlefield on resistive system In 1957, Glick Fabricius found out that Chicken without bursa deal not produce Ab -B cell In 1961,Good and milling machine - Cell mediated repellent of new born mice whose thymus gland were taken absent are unfit -T cell 2. line of business on m onoclonal antibody -In 1975, Kohler and Milstein 3. battleground on immune ancestrals -In 1978, genetic control of antibody regeneration -Discovery of accurate machine of immune reaction on gene level (MHC, TCR , BCR) 4. call for on molecular machine of T/B lymphocyte activation and argue transduction 5. accept on effective mechanism of immune cells NTTH-HCMIU-IMMUN-2013 6. Study on clinical immunology Organ transplant Autoimmune disease Tumor immunology Infectious diseases 7.Study on applied immunology readying of monoclonal antibody and genetic engine room antibody Preparation of recombinant cytokines Study on desoxyribonucleic acid vaccine Study on treatment with immune cells 8. juvenile proficiencys of modern immunology and natural covering Separation of immune cells Protein analysis technique Phage unwrap technique Preparation of new animal model NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 The immune system insubordinate system Innate (non- specific) immunity reconciling (specific) immunity anatomical barriers (Skin,mucous membranes) Physological barriers (temperature, pH) Phagocytic Barriers (cells that eat invaders) Inflammatory barriers (redness, swelling, hot up and pain) Antigen specificity Diversity immunologic memory self/nonself recognition NTTH-HCMIU-IMMUN-2013 Our immune systems generate an around infinite manakin of cells and substances Foreign credit entry Memory Upon 2 exposure produces deepen response effecter Response To croak or scratch off particle *In some cases, the IR fails to function at other times, the IR can bite on its hostNTTH-HCMIU-IMMUN-2013 Humoral and cellular immunity (antibody mediated or cellular) NTTH-HCMIU-IMMUN-2013 B cells step up bound antibody Antibody secreting B cell Antigen B-cell Soluble antibodies, circculate in the body NTTH-HCMIU-IMMUN-2013 Antibody secreting B cell B-cell Virus killed NTTH-HCMIU-IMMUN-2013 interchange Topics 1. Why do warm-blooded, long-lived animals solicit particularly intricate immune defense? p4-DIR 2. Why would remotion of Ag behave to the decline in an immune response? p14-DIR And many to a greater extent to explore in the DIR textbookHome works P18-DIR NTTH-HCMIU-IMMUN-2013 The real ones Crawling Macrophage neutrophile and DCs NTTH-HCMIU-IMMUN-2013 Introduction to IMMUNOLOGY- An X soup What is Immunology? What is Immune System (IS)? History of Immunology Cells and Soluble Mediators of IS= ? Immune Respone- Pathogens (Ags) Innate and adaptative Immunity- Collaboration Read DIR-page 1-18 NTTH-HCMIU-IMMUN-2013 Once upon a time on that point was a WARGAMES OF THRONES- consider OF LIVE OR DIE HAS IT already ENDED? NO, IT IS estimable A commence NTTH-HCMIU-IMMUN-2013